Sitagliptin

Catalog No. A14377

Sitagliptin是二肽基肽酶-4（DPP-4）抑制剂类别降糖药（抗糖尿病药）。

Product Citations

Hae Jin Kim, .et al. Potentiation of endothelium-dependent vasorelaxation of mesenteric arteries from spontaneously hypertensive rats by gemigliptin, a dipeptidyl peptidase-4 inhibitor class of anti-diabetic drug, Korean J Physiol Pharmacol, 2018, Nov; 22(6): 713-719 PMID: 30402032
Chintan N. Koyani, .et al. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes, Front Physiol, 2018, 9: 1622 PMID: 30487758

Technical details

Catalog Num	A14377
M. Wt	407.31
Formula	C16H15F6N5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	486460-32-6
Synonyms	MK-0431, MK 0431, MK0431
SMILES	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N

Biological Activity

Sitagliptin是二肽基肽酶-4（DPP-4）抑制剂类别降糖药（抗糖尿病药）。

Solubility *

In vitro	DMSO	79 mg/mL (193.95 mM)
	Water
	Ethanol
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.55 mL	122.76 mL	245.51 mL
0.5 mM	4.91 mL	24.55 mL	49.1 mL
1 mM	2.46 mL	12.28 mL	24.55 mL
5 mM	0.49 mL	2.46 mL	4.91 mL

*The above data is based on the productmolecular weight 407.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.