INCB39110 (Itacitinib)

Catalog No. A14390

INCB39110 (Itacitinib)是一种有效的JAK1酪氨酸激酶抑制剂，目前正在II期试验中，用于治疗类风湿关节炎，骨髓纤维化，类风湿关节炎和斑块状牛皮癣。

Product Citations

Czech J, .et al. JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation, Leukemia, 2018, Nov 23 PMID: 30470838

Technical details

Catalog Num	A14390
M. Wt	553.51
Formula	C26H23F4N9O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1334298-90-6
Synonyms	INCB 39110, INCB-39110, INCB039110, INCB-039110, INCB 039110
SMILES	N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1

Biological Activity

INCB39110 (Itacitinib)是一种有效的JAK1酪氨酸激酶抑制剂，目前正在II期试验中，用于治疗类风湿关节炎，骨髓纤维化，类风湿关节炎和斑块状牛皮癣。

Solubility *

In vitro	DMSO	88 mg/mL (158.98 mM)
	Water	Insoluble
	Ethanol	88 mg/mL (158.98 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.07 mL	90.33 mL	180.67 mL
0.5 mM	3.61 mL	18.07 mL	36.13 mL
1 mM	1.81 mL	9.03 mL	18.07 mL
5 mM	0.36 mL	1.81 mL	3.61 mL

*The above data is based on the productmolecular weight 553.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.