CB-839

Catalog No. A14396

CB-839 an是谷氨酰胺酶的生物利用抑制剂，具有潜在的抗肿瘤活性。

Product Citations

Beatriz Giesen, .et al. Augmented Therapeutic Potential of Glutaminase Inhibitor CB839 in Glioblastoma Stem Cells Using Gold Nanoparticle Delivery, Pharmaceutics, 2021, Feb 23;13(2):295 PMID: 33672398

Technical details

Catalog Num	A14396
M. Wt	571.57
Formula	C26H24F3N7O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1439399-58-2
Synonyms	CB839, CB 839
SMILES	O=C(CC1=CC=CC(OC(F)(F)F)=C1)NC2=CC=C(CCCCC3=NN=C(NC(CC4=NC=CC=C4)=O)S3)N=N2

Biological Activity

CB-839 an是谷氨酰胺酶的生物利用抑制剂，具有潜在的抗肿瘤活性。

Targets

glutaminase
24 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 97 mg/mL (169.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.5 mL	87.48 mL	174.96 mL
0.5 mM	3.5 mL	17.5 mL	34.99 mL
1 mM	1.75 mL	8.75 mL	17.5 mL
5 mM	0.35 mL	1.75 mL	3.5 mL

*The above data is based on the productmolecular weight 571.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.