Molidustat

Catalog No. A14404

Molidustat是一种新型的低氧诱导因子（HIF）脯氨酰羟化酶（PH）抑制剂，可刺激促红细胞生成素（EPO）的产生和红细胞的形成。

Technical details

Catalog Num	A14404
M. Wt	314.3
Formula	C13H14N8O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1154028-82-6
Synonyms	BAY 85-3934, BAY85-3934, BAY853934
SMILES	C1COCCN1C2=NC=NC(=C2)N3C(=O)C(=CN3)N4C=CN=N4

Biological Activity

Molidustat是一种新型的低氧诱导因子（HIF）脯氨酰羟化酶（PH）抑制剂，可刺激促红细胞生成素（EPO）的产生和红细胞的形成。

Targets

PHD2	PHD3	PHD1
280 nM	450 nM	480 nM

Solubility *

In vitro	DMSO	Warmed: 3 mg/mL (9.54 mM)
	Water	Insoluble
	Ethanol	DMF: 4 mg/mL (12.72 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.82 mL	159.08 mL	318.17 mL
0.5 mM	6.36 mL	31.82 mL	63.63 mL
1 mM	3.18 mL	15.91 mL	31.82 mL
5 mM	0.64 mL	3.18 mL	6.36 mL

*The above data is based on the productmolecular weight 314.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.