GKT137831

Catalog No. A14433

GKT137831是针对NOX1和NOX4酶的一流抑制剂。

Product Citations

Chia-Hui Huang, .et al. Arsenic Trioxide-Induced p38 MAPK and Akt Mediated MCL1 Downregulation Causes Apoptosis of BCR-ABL1-positive Leukemia Cells, Toxicol Appl Pharmacol, 2020, Apr 17;397:115013 PMID: 32305283

Technical details

Catalog Num	A14433
M. Wt	394.85
Formula	C21H19ClN4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1218942-37-0
Synonyms	GKT-137831, GKT 137831
SMILES	CN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl

Biological Activity

GKT137831是针对NOX1和NOX4酶的一流抑制剂。

Targets

NOX1	NOX4
110 nM(Ki)	140 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	Warmed: 72 mg/mL (182.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+2% Tween 80+30% PEG 300+ddH2O	8 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.33 mL	126.63 mL	253.26 mL
0.5 mM	5.07 mL	25.33 mL	50.65 mL
1 mM	2.53 mL	12.66 mL	25.33 mL
5 mM	0.51 mL	2.53 mL	5.07 mL

*The above data is based on the productmolecular weight 394.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.