FTI-277 HCl

Catalog No. A14439

FTI-277 HCl是法呢基转移酶（FTase）的抑制剂。一种高效的Ras CAAX拟肽药物，可拮抗H-Ras和K-Ras致癌信号。

Technical details

Catalog Num	A14439
M. Wt	484.07
Formula	C22H30ClN3O3S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	180977-34-8
Synonyms	FTI 277, FTI277
SMILES	COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.Cl.Cl

Biological Activity

FTI-277 HCl是法呢基转移酶（FTase）的抑制剂。一种高效的Ras CAAX拟肽药物，可拮抗H-Ras和K-Ras致癌信号。

Targets

FTase	GGTase I
500 pM	50 nM

Solubility *

In vitro	DMSO	90 mg/mL (185.92 mM)
	Water	16 mg/mL (33.04 mM)
	Ethanol	Warmed: 13 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.66 mL	103.29 mL	206.58 mL
0.5 mM	4.13 mL	20.66 mL	41.32 mL
1 mM	2.07 mL	10.33 mL	20.66 mL
5 mM	0.41 mL	2.07 mL	4.13 mL

*The above data is based on the productmolecular weight 484.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.