12-O-tetradecanoyl phorbol-13-acetate

Catalog No. A14616

12-O-tetradecanoyl phorbol-13-acetate是佛波醇的二酯，是从巴豆油中提取的促肿瘤化合物。它是在体内和体外以nM浓度可逆的高效蛋白激酶C（PKC）激活剂。

Product Citations

孙哲 ,etc. 右美托咪定对痛觉过敏大鼠脊髓 PKCγ, CaMKⅡα 及 pCaMKⅡα 表达的影响. 天津医药, 2016, 44(6), 700-703.

Technical details

Catalog Num	A14616
M. Wt	616.83
Formula	C36H56O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	16561-29-8
Synonyms	TPA, Phorbol 12-myristate 13-acetate
SMILES	CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

Biological Activity

12-O-tetradecanoyl phorbol-13-acetate是佛波醇的二酯，是从巴豆油中提取的促肿瘤化合物。它是在体内和体外以nM浓度可逆的高效蛋白激酶C（PKC）激活剂。

Solubility *

In vitro	DMSO	94 mg/mL (152.38 mM)
	Water	Insoluble
	Ethanol	94 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.21 mL	81.06 mL	162.12 mL
0.5 mM	3.24 mL	16.21 mL	32.42 mL
1 mM	1.62 mL	8.11 mL	16.21 mL
5 mM	0.32 mL	1.62 mL	3.24 mL

*The above data is based on the productmolecular weight 616.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.