Wedelolactone

Catalog No. A14804

Wedelolactone是最初从白花苜蓿中提取的化合物，已显示出抑制caspase-11的作用，而caspase-11是促炎性细胞因子IL-1β成熟和病理性细胞凋亡的关键调节剂。

Product Citations

Shigetoshi Yokoyama, .et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 PMID: 30526845

Technical details

Catalog Num	A14804
M. Wt	314.3
Formula	C16H10O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	524-12-9
Synonyms	IKK Inhibitor II, Eclipta alba
SMILES	COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O

Biological Activity

Wedelolactone是最初从白花苜蓿中提取的化合物，已显示出抑制caspase-11的作用，而caspase-11是促炎性细胞因子IL-1β成熟和病理性细胞凋亡的关键调节剂。

Solubility *

In vitro	DMSO	60 mg/mL (190.92 mM)
	Water
	Ethanol
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.82 mL	159.08 mL	318.17 mL
0.5 mM	6.36 mL	31.82 mL	63.63 mL
1 mM	3.18 mL	15.91 mL	31.82 mL
5 mM	0.64 mL	3.18 mL	6.36 mL

*The above data is based on the productmolecular weight 314.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.