Q-VD-OPh hydrate

Catalog No. A14915

Q-VD-OPh hydrate是一种选择性，脑和细胞可渗透的，高效且不可逆的caspase-3（IC50 = 25nm），caspase-1（IC50 = 50nM），caspase-8（IC50 = 100nM）和caspase-9抑制剂（IC50 ＝ 430nM）。

Product Citations

Anna L Koessinger, .et al. Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics, Cell Death Differ, 2022, Apr 26 PMID: 35473984
Florian J Bock, .et al. Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death, Nat Commun, 2021, Nov 12;12(1):6572 PMID: 34772930
Davide Pradella, .et al. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis, Nat Commun, 2021, 12: 4872 PMID: 34381052
Haschka MD, .et al. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment, Cell Death Differ, 2020, Feb 3 PMID: 32015503

Technical details

Catalog Num	A14915
M. Wt	513.49
Formula	C26H25F2N3O6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1135695-98-5
Synonyms
SMILES	CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2

Biological Activity

Targets

Caspase-1	Caspase-3	Caspase-8	Caspase-9
25 nM-400 nM	25 nM-400 nM	25 nM-400 nM	25 nM-400 nM

Solubility *

In vitro	DMSO	94 mg/mL (183.06 mM)
	Water	Insoluble
	Ethanol	94 mg/mL (183.06 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.47 mL	97.37 mL	194.75 mL
0.5 mM	3.89 mL	19.47 mL	38.95 mL
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.