S-Ruxolitinib

Catalog No. A14955

S-Ruxolitinib是INCB018424的手性化合物,是一种有效且选择性的小分子Janus激酶1(JAK1)和JAK2抑制剂。
Catalog Num A14955
M. Wt 306.37
Formula C17H18N6
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 941685-37-6
Synonyms INCB018424
SMILES C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
S-Ruxolitinib是INCB018424的手性化合物,是一种有效且选择性的小分子Janus激酶1(JAK1)和JAK2抑制剂。
Targets
Target Value
JAK2IC50: 2.8nM
JAK1IC50: 3.3nM
TYK2IC50: 19nM
JAK3IC50: 428nM
Chk2IC50: >1μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 59 mg/mL (192.57 mM)
Water 5 mg/mL (16.32 mM)
Ethanol 59 mg/mL (192.57 mM)
In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.64 mL 163.2 mL 326.4 mL
0.5 mM 6.53 mL 32.64 mL 65.28 mL
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL

*The above data is based on the productmolecular weight 306.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.