S-Ruxolitinib
Catalog No. A14955
S-Ruxolitinib是INCB018424的手性化合物,是一种有效且选择性的小分子Janus激酶1(JAK1)和JAK2抑制剂。
Catalog Num | A14955 |
---|---|
M. Wt | 306.37 |
Formula | C17H18N6 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 941685-37-6 |
Synonyms | INCB018424 |
SMILES | C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
S-Ruxolitinib是INCB018424的手性化合物,是一种有效且选择性的小分子Janus激酶1(JAK1)和JAK2抑制剂。
Targets
Target | Value |
---|---|
JAK2 | IC50: 2.8nM |
JAK1 | IC50: 3.3nM |
TYK2 | IC50: 19nM |
JAK3 | IC50: 428nM |
Chk2 | IC50: >1μM |
c-Met | IC50: >10μM |
In vitro (25°C) | DMSO | 59 mg/mL (192.57 mM) | |
Water | 5 mg/mL (16.32 mM) | ||
Ethanol | 59 mg/mL (192.57 mM) | ||
In vivo | 0.5% CMC+0.25% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 32.64 mL | 163.2 mL | 326.4 mL |
0.5 mM | 6.53 mL | 32.64 mL | 65.28 mL |
1 mM | 3.26 mL | 16.32 mL | 32.64 mL |
5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
*The above data is based on the productmolecular weight 306.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.