A 438079 hydrochloride

Catalog No. A14983

A 438079 hydrochloride是一种竞争性P2X7受体拮抗剂（抑制人重组P2X7细胞系中Ca2+流入的pIC50 = 6.9）。

Product Citations

Zhihua Yi, .et al. Andrographolide Inhibits Mechanical and Thermal Hyperalgesia in a Rat Model of HIV-Induced Neuropathic Pain, Front Pharmacol, 2018, 9: 593 PMID: 29950989

Technical details

Catalog Num	A14983
M. Wt	342.61
Formula	C13H10Cl3N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	899431-18-6
Synonyms
SMILES	C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl

Biological Activity

A 438079 hydrochloride是一种竞争性P2X7受体拮抗剂（抑制人重组P2X7细胞系中Ca2+流入的pIC50 = 6.9）。

Targets

P2X7 receptor
6.9(pIC50)

Solubility *

In vitro (25°C)	DMSO	55 mg/mL (160.53 mM)
	Water	55 mg/mL (160.53 mM)
	Ethanol	Warmed: 18 mg/mL (52.53 mM)
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.19 mL	145.94 mL	291.88 mL
0.5 mM	5.84 mL	29.19 mL	58.38 mL
1 mM	2.92 mL	14.59 mL	29.19 mL
5 mM	0.58 mL	2.92 mL	5.84 mL

*The above data is based on the productmolecular weight 342.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.