Dasatinib hydrochloride

Catalog No. A15060

Dasatinib hydrochloride是一种有效的Abl/Src双重抑制剂,IC50分别<1 nM/0.8 nM。还可以抑制c-Kit(WT/c-Kit(D816V),IC50为79 nM/37 nM。有效,选择性Raf激酶抑制剂能够抑制野生型B-Raf,B-RafV600E和c -Raf的IC50值分别为3.2、0.8和5.0 nM。
Catalog Num A15060
M. Wt 524.47
Formula C22H27Cl2N7O2S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 854001-07-3
Synonyms BMS-354825 hydrochloride, Sprycel hydrochloride, BMS354825 hydrochloride, BMS 354825 hydrochloride
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C.Cl
Dasatinib hydrochloride是一种有效的Abl/Src双重抑制剂,IC50分别<1 nM/0.8 nM。还可以抑制c-Kit(WT/c-Kit(D816V),IC50为79 nM/37 nM。有效,选择性Raf激酶抑制剂能够抑制野生型B-Raf,B-RafV600E和c -Raf的IC50值分别为3.2、0.8和5.0 nM。
In vitro DMSO 85 mg/mL (162.06 mM)
Water
Ethanol
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.07 mL 95.33 mL 190.67 mL
0.5 mM 3.81 mL 19.07 mL 38.13 mL
1 mM 1.91 mL 9.53 mL 19.07 mL
5 mM 0.38 mL 1.91 mL 3.81 mL

*The above data is based on the productmolecular weight 524.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.