SLx-2119 (KD025)

Catalog No. A15239

SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂，IC50为105 nM。在ROCK1上的选择性> 200倍（IC50 = 24 uM）。

Technical details

Catalog Num	A15239
M. Wt	452.51
Formula	C26H24N6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	911417-87-3
Synonyms	SLx 2119, SLx2119, ROCK inhibitor, KD-025
SMILES	CC(C)NC(=O)COC1=CC=CC(=C1)C2=NC3=CC=CC=C3C(=N2)NC4=CC5=C(C=C4)NN=C5

Biological Activity

SLx-2119 (KD025)是ROCK2的小分子和选择性抑制剂，IC50为105 nM。在ROCK1上的选择性> 200倍（IC50 = 24 uM）。

Targets

ROCK2	ROCK2
41 nM(Ki)	60 nM

Solubility *

In vitro (25°C)	DMSO	84 mg/mL (185.63 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+35% PEG 300+2%Tween 80+ddH2O	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.1 mL	110.49 mL	220.99 mL
0.5 mM	4.42 mL	22.1 mL	44.2 mL
1 mM	2.21 mL	11.05 mL	22.1 mL
5 mM	0.44 mL	2.21 mL	4.42 mL

*The above data is based on the productmolecular weight 452.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.