TRV130 HCl (Oliceridine)
Catalog No. A15444
TRV130 HCl (Oliceridine)是一种新型的μ-opioid 受体（MOR）G蛋白偏向配体。诱导强大的G蛋白信号传导（pEC50 = 8.1），效力和功效与吗啡相似，但β-arrestin募集和受体内在化作用要低得多。
- Preeti Manandhar, .et al. Tapentadol shows lower intrinsic efficacy at μ receptor than morphine and oxycodone, Pharmacol Res Perspect, 2022, 10:e00921 PMID: 35084120
- Li He, .et al. Pharmacological and genetic manipulations at the ?-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice, Neuropsychopharmacology, 2021, 13 July PMID: 34257415
| Catalog Num | A15444 |
|---|---|
| M. Wt | 423.01 |
| Formula | C22H31ClN2O2S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1401031-39-7 |
| Synonyms | TRV-130, TRV 130 |
| SMILES | COC1=C(SC=C1)CNCCC2(CCOC3(C2)CCCC3)C4=CC=CC=N4.Cl |
TRV130 HCl (Oliceridine)是一种新型的μ-opioid 受体（MOR）G蛋白偏向配体。诱导强大的G蛋白信号传导（pEC50 = 8.1），效力和功效与吗啡相似，但β-arrestin募集和受体内在化作用要低得多。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.64 mL | 118.2 mL | 236.4 mL |
| 0.5 mM | 4.73 mL | 23.64 mL | 47.28 mL |
| 1 mM | 2.36 mL | 11.82 mL | 23.64 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.73 mL |
*The above data is based on the productmolecular weight 423.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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