UNC0642
Catalog No. A15487
UNC0642是有效的选择性G9a和GLP组蛋白赖氨酸甲基转移酶抑制剂(IC50 <2.5 nM)。它降低了MDA-MB-231细胞中的H3K9二甲基化水平(IC50 = 110 nM)。在体内显示适度的大脑渗透。
Catalog Num | A15487 |
---|---|
M. Wt | 546.69 |
Formula | C29H44F2N6O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1481677-78-4 |
Synonyms | UNC 0642, UNC-0642 |
SMILES | CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F |
UNC0642是有效的选择性G9a和GLP组蛋白赖氨酸甲基转移酶抑制剂(IC50 <2.5 nM)。它降低了MDA-MB-231细胞中的H3K9二甲基化水平(IC50 = 110 nM)。在体内显示适度的大脑渗透。
In vitro | DMSO | 88 mg/mL (160.96 mM) | |
Water | Insoluble | ||
Ethanol | 88 mg/mL (160.96 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.29 mL | 91.46 mL | 182.92 mL |
0.5 mM | 3.66 mL | 18.29 mL | 36.58 mL |
1 mM | 1.83 mL | 9.15 mL | 18.29 mL |
5 mM | 0.37 mL | 1.83 mL | 3.66 mL |
*The above data is based on the productmolecular weight 546.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.