PF-06447475

Catalog No. A15504

PF-06447475是一种高效，选择性，脑渗透性LRRK2抑制剂，对Wt LRRK2/G2019S LRRK2的IC50分别为3 nM/11 nM。

Technical details

Catalog Num	A15504
M. Wt	305.33
Formula	C17H15N5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1527473-33-1
Synonyms	PF06447475, PF 06447475
SMILES	C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N

Biological Activity

PF-06447475是一种高效，选择性，脑渗透性LRRK2抑制剂，对Wt LRRK2/G2019S LRRK2的IC50分别为3 nM/11 nM。

Targets

LRRK2	G2019S LRRK2
3nM	11nM

Solubility *

In vitro	DMSO	56 mg/mL (183.4 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.75 mL	163.76 mL	327.51 mL
0.5 mM	6.55 mL	32.75 mL	65.5 mL
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL

*The above data is based on the productmolecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.