AZ5104

Catalog No. A15516

AZD-9291的去甲基代谢产物AZ5104是一种有效的EGFR抑制剂，对于EGFR（L858R/T790M），EGFR（L858R），EGFR（L861Q）和EGFR，IC50 <1 nM，6 nM，1 nM和25 nM EGFR（野生型）。

Technical details

Catalog Num	A15516
M. Wt	485.58
Formula	C27H31N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1421373-98-9
Synonyms	AZ-5104, AZ 5104
SMILES	CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC

Biological Activity

Targets

Target	Value
EGFR(L858R/T790M)	IC50: <1nM
EGFR(L861Q)	IC50: 1nM
EGFR(L858R)	IC50: 6nM
ErbB4	IC50: 7nM
EGFR(wildtype)	IC50: 25nM
ACK1	IC50: 27nM
BLK	IC50: 27nM
BRK	IC50: 45nM
MNK2	IC50: 62nM
IGF1-R	IC50: 78nM
ALK	IC50: 97nM
TEC	IC50: 118nM
FES	IC50: 127nM
InsR	IC50: 127nM
FLT3	IC50: 129nM
BTK	IC50: 132nM
FAK	IC50: 136nM
MLK1	IC50: 141nM
FLT4	IC50: 142nM
PYK2	IC50: 284nM
IRR	IC50: 423nM
Txk	IC50: 426nM
BMX	IC50: 505nM
ITK	IC50: 925nM
JAK3	IC50: 1358nM

Solubility *

In vitro (25°C)	DMSO	90 mg/mL (185.34 mM)
	Water	Insoluble
	Ethanol	Warmed: 21 mg/mL (43.24 mM)
In vivo	1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.59 mL	102.97 mL	205.94 mL
0.5 mM	4.12 mL	20.59 mL	41.19 mL
1 mM	2.06 mL	10.3 mL	20.59 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

*The above data is based on the productmolecular weight 485.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.