Purvalanol A

Catalog No. A15517

Purvalanol A是一种有效的细胞渗透性细胞周期蛋白依赖性蛋白激酶（cdk）抑制剂。对于cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35，IC50值分别为4、70、35、850和75 nM。

Technical details

Catalog Num	A15517
M. Wt	388.89
Formula	C19H25ClN6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	212844-53-6
Synonyms	NG-60
SMILES	CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1

Biological Activity

Targets

Cdc2/CyclinB	CDK2/CyclinE	CDK2/CyclinA	CDK4/CyclinD1
4 nM	35 nM	70 nM	850 nM

Solubility *

In vitro	DMSO	Warmed: 53 mg/mL (136.28 mM)
	Water	Insoluble
	Ethanol	Warmed: 11 mg/mL (28.28 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.71 mL	128.57 mL	257.14 mL
0.5 mM	5.14 mL	25.71 mL	51.43 mL
1 mM	2.57 mL	12.86 mL	25.71 mL
5 mM	0.51 mL	2.57 mL	5.14 mL

*The above data is based on the productmolecular weight 388.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.