G007-LK

Catalog No. A15528

G007-LK对坦科聚合酶1和2具有很高的选择性，生化IC50值分别为46 nM和25 nM，细胞IC50值为50 nM，并具有出色的小鼠药代动力学特征，

Product Citations

Dominic B. Bernkopf, .et al. An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy, Nat Commun, 2019, 10:4251 PMID: 31534175

Technical details

Catalog Num	A15528
M. Wt	529.96
Formula	C25H16ClN7O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1380672-07-0
Synonyms	G007 LK, G007LK
SMILES	CS(=O)(=O)C1=CN=C(C=C1)C2=NN=C(N2C3=CC=CC=C3Cl)C=CC4=NN=C(O4)C5=CC=C(C=C5)C#N

Biological Activity

G007-LK对坦科聚合酶1和2具有很高的选择性，生化IC50值分别为46 nM和25 nM，细胞IC50值为50 nM，并具有出色的小鼠药代动力学特征，

Targets

Solubility *

In vitro	DMSO	98 mg/mL (184.92 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.87 mL	94.35 mL	188.69 mL
0.5 mM	3.77 mL	18.87 mL	37.74 mL
1 mM	1.89 mL	9.43 mL	18.87 mL
5 mM	0.38 mL	1.89 mL	3.77 mL

*The above data is based on the productmolecular weight 529.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.