BLZ945

Catalog No. A15540

BLZ945是有效的选择性CSF-1R激酶抑制剂。它减弱了TAM的周转率，同时增加了浸润宫颈癌和乳腺癌的CD8+ T细胞的数量。

Technical details

Catalog Num	A15540
M. Wt	398.4
Formula	C20H22N4O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	953769-46-5
Synonyms	BLZ 945, BLZ-945
SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O

Biological Activity

BLZ945是有效的选择性CSF-1R激酶抑制剂。它减弱了TAM的周转率，同时增加了浸润宫颈癌和乳腺癌的CD8+ T细胞的数量。

Targets

CSF-1R
1 nM

Solubility *

In vitro (25°C)	DMSO	77 mg/mL (193.23 mM)
	Water	Insoluble
	Ethanol	Warmed: 3 mg/mL
In vivo	4% DMSO+30% PEG 300+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.1 mL	125.5 mL	251 mL
0.5 mM	5.02 mL	25.1 mL	50.2 mL
1 mM	2.51 mL	12.55 mL	25.1 mL
5 mM	0.5 mL	2.51 mL	5.02 mL

*The above data is based on the productmolecular weight 398.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.