Epacadostat (INCB024360)

Catalog No. A15554

Epacadostat (INCB024360)是一种有效的选择性吲哚胺2,3-二加氧酶（IDO1）抑制剂，第2期的IC50为10 nM。

Product Citations

Marta Galan-Diez, .et al. Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia, Cancer Discov, 2022, Apr 1;12(4):1106-1127 PMID: 35046097

Technical details

Catalog Num	A15554
M. Wt	438.23
Formula	C11H13BrFN7O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1204669-58-8, 1204669-37-3
Synonyms	INCB 024360
SMILES	C1=CC(=C(C=C1NC(=C2C(=NON2)NCCNS(=O)(=O)N)N=O)Br)F

Biological Activity

Epacadostat (INCB024360)是一种有效的选择性吲哚胺2,3-二加氧酶（IDO1）抑制剂，第2期的IC50为10 nM。

Targets

IDO1
10 nM

Solubility *

In vitro (25°C)	DMSO	74 mg/mL (168.86 mM)
	Water	Insoluble
	Ethanol	Warmed: 45 mg/mL
In vivo	5% DMSO+40% PEG 300+5% TWEEN 80+50 % ddH2O	4.13 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.82 mL	114.1 mL	228.19 mL
0.5 mM	4.56 mL	22.82 mL	45.64 mL
1 mM	2.28 mL	11.41 mL	22.82 mL
5 mM	0.46 mL	2.28 mL	4.56 mL

*The above data is based on the productmolecular weight 438.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.