SBI-0206965

Catalog No. A15795

SBI-0206965是一种有效的，选择性的且细胞可渗透的自噬激酶ULK1抑制剂，对于ULK1激酶活性，IC50为108 nM；对于高度相关的激酶ULK2，IC50为711 nM。

Product Citations

SR Bonam, .et al. Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo, Cells, 2020, May; 9(5): 1321 PMID: 32466347
Altea Rocchi, .et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease, PLoS Genet, 2017, Aug; 13(8): e1006962 PMID: 28806762

Technical details

Catalog Num	A15795
M. Wt	489.32
Formula	C21H21BrN4O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1884220-36-3
Synonyms	SBI 0206965, SBI0206965
SMILES	CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(C(=C3)OC)OC)OC

Biological Activity

SBI-0206965是一种有效的，选择性的且细胞可渗透的自噬激酶ULK1抑制剂，对于ULK1激酶活性，IC50为108 nM；对于高度相关的激酶ULK2，IC50为711 nM。

Solubility *

In vitro	DMSO	90 mg/mL (183.92 mM)
	Water	Insoluble
	Ethanol	Warmed: 9 mg/mL (18.39 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.44 mL	102.18 mL	204.37 mL
0.5 mM	4.09 mL	20.44 mL	40.87 mL
1 mM	2.04 mL	10.22 mL	20.44 mL
5 mM	0.41 mL	2.04 mL	4.09 mL

*The above data is based on the productmolecular weight 489.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.