SW033291

Catalog No. A15798

SW033291是15-PGDH的小分子抑制剂（Ki = 0.1 nM），可增加骨髓和其他组织中前列腺素PGE2的水平。

Technical details

Catalog Num	A15798
M. Wt	412.59
Formula	C21H20N2OS3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	459147-39-8
Synonyms	SW 033291, SW-033291
SMILES	NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

Biological Activity

SW033291是15-PGDH的小分子抑制剂（Ki = 0.1 nM），可增加骨髓和其他组织中前列腺素PGE2的水平。

Targets

15-PGDH	15-PGDH
0.1 nM(Ki)	1.5 nM

Solubility *

In vitro (25°C)	DMSO	77 mg/mL (186.62 mM)
	Water	Insoluble
	Ethanol	Warmed: 30 mg/mL (72.7 mM)
In vivo	5% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.24 mL	121.19 mL	242.37 mL
0.5 mM	4.85 mL	24.24 mL	48.47 mL
1 mM	2.42 mL	12.12 mL	24.24 mL
5 mM	0.48 mL	2.42 mL	4.85 mL

*The above data is based on the productmolecular weight 412.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.