Entrectinib

Catalog No. A15801

Entrectinib，也称为RXDX-101和NMS-E628，是TrkA，TrkB和TrkC以及ROS1和ALK的小分子抑制剂，具有很高的效力和选择性。

Technical details

Catalog Num	A15801
M. Wt	560.64
Formula	C31H34F2N6O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1108743-60-7
Synonyms	RXDX-101, RXDX-101, RXDX-101, NMS E628, NMS-E628, NMSE628
SMILES	CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6

Biological Activity

Entrectinib，也称为RXDX-101和NMS-E628，是TrkA，TrkB和TrkC以及ROS1和ALK的小分子抑制剂，具有很高的效力和选择性。

Targets

TrkA	TrkB	TrkC	ROS1	ALK

Solubility *

In vitro	DMSO	89 mg/mL (158.74 mM)
	Water	Insoluble
	Ethanol	67 mg/mL (119.5 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.84 mL	89.18 mL	178.37 mL
0.5 mM	3.57 mL	17.84 mL	35.67 mL
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL

*The above data is based on the productmolecular weight 560.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.