ACP-196 (Acalabrutinib)

Catalog No. A15824

ACP-196是Bruton酪氨酸激酶(BTK)抑制剂,具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体(BCR)信号传导途径的激活。
Catalog Num A15824
M. Wt 465.52
Formula C26H23N7O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1420477-60-6
Synonyms Acalabrutinib, ACP196, ACP 196
SMILES CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5
ACP-196是Bruton酪氨酸激酶(BTK)抑制剂,具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体(BCR)信号传导途径的激活。
Targets
BTK
3nM
In vitro (25°C) DMSO 80 mg/mL (171.85 mM)
Water Insoluble
Ethanol 80 mg/mL (171.85 mM)
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.81 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.