ACP-196 (Acalabrutinib)
Catalog No. A15824
ACP-196是Bruton酪氨酸激酶(BTK)抑制剂,具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体(BCR)信号传导途径的激活。
Catalog Num | A15824 |
---|---|
M. Wt | 465.52 |
Formula | C26H23N7O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1420477-60-6 |
Synonyms | Acalabrutinib, ACP196, ACP 196 |
SMILES | CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5 |
ACP-196是Bruton酪氨酸激酶(BTK)抑制剂,具有潜在的抗肿瘤活性。它抑制BTK的活性并阻止B细胞抗原受体(BCR)信号传导途径的激活。
Targets
BTK | ||||
3nM |
In vitro (25°C) | DMSO | 80 mg/mL (171.85 mM) | |
Water | Insoluble | ||
Ethanol | 80 mg/mL (171.85 mM) | ||
In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 5 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.48 mL | 107.41 mL | 214.81 mL |
0.5 mM | 4.3 mL | 21.48 mL | 42.96 mL |
1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.