PLX7904

Catalog No. A15855

PLX7904是有效的选择性悖论突破性RAF抑制剂。它能够有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活，但不能过度激活突变型RAS表达细胞中的ERK1/2。

Technical details

Catalog Num	A15855
M. Wt	512.53
Formula	C24H22F2N6O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1393465-84-3
Synonyms	PB04
SMILES	O=C(C1=CNC2=NC=C(C3=CN=C(C4CC4)N=C3)C=C21)C5=C(F)C=CC(NS(=O)(N(CC)C)=O)=C5F

Biological Activity

PLX7904是有效的选择性悖论突破性RAF抑制剂。它能够有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活，但不能过度激活突变型RAS表达细胞中的ERK1/2。

Targets

Raf

Solubility *

In vitro	DMSO	87 mg/mL (169.75 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.51 mL	97.56 mL	195.11 mL
0.5 mM	3.9 mL	19.51 mL	39.02 mL
1 mM	1.95 mL	9.76 mL	19.51 mL
5 mM	0.39 mL	1.95 mL	3.9 mL

*The above data is based on the productmolecular weight 512.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.