SGI-7079

Catalog No. A15864

SGI-7079是一种新型的选择性Axl抑制剂，以剂量依赖的方式抑制肿瘤的生长，并且是克服EGFR抑制剂耐药性的潜在治疗靶标。

Technical details

Catalog Num	A15864
M. Wt	455.53
Formula	C26H26FN7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1239875-86-5
Synonyms	SGI7079, SGI 7079
SMILES	N#CCC1=CC=CC(C2=C3C(NC=C3C)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1

Biological Activity

SGI-7079是一种新型的选择性Axl抑制剂，以剂量依赖的方式抑制肿瘤的生长，并且是克服EGFR抑制剂耐药性的潜在治疗靶标。

Targets

Target	Value
Met
Mer
YES
RET
FLT3
Axl	IC50: 58nM

Solubility *

In vitro	DMSO	77 mg/mL (169.03 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.95 mL	109.76 mL	219.52 mL
0.5 mM	4.39 mL	21.95 mL	43.9 mL
1 mM	2.2 mL	10.98 mL	21.95 mL
5 mM	0.44 mL	2.2 mL	4.39 mL

*The above data is based on the productmolecular weight 455.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.