AS1842856

Catalog No. A15871

AS1842856是细胞渗透性抑制剂，可阻断Foxo1的转录活性，IC50为33 nM。它可以直接与活性Foxo1结合，但不能与Ser256磷酸化形式结合。

Product Citations

Yuta Tanizaki, .et al. Thyroid hormone receptor α controls larval intestinal epithelial cell death by regulating the CDK1 pathway, Commun Biol, 2022, 5: 112 PMID: 35132135
Zhongsheng Zhu, .et al. Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway, BMC Complement Altern Med, 2019, 19: 111 PMID: 31146723

Technical details

Catalog Num	A15871
M. Wt	347.38
Formula	C18H22FN3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	836620-48-5
Synonyms	AS 1842856, AS-1842856
SMILES	O=C1C(C(O)=O)=CN(CC)C2=C1C(N)=C(F)C(NC3CCCCC3)=C2

Biological Activity

AS1842856是细胞渗透性抑制剂，可阻断Foxo1的转录活性，IC50为33 nM。它可以直接与活性Foxo1结合，但不能与Ser256磷酸化形式结合。

Targets

Foxo1
33nM

Solubility *

In vitro	DMSO	23 mg/mL (66.2 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.79 mL	143.93 mL	287.87 mL
0.5 mM	5.76 mL	28.79 mL	57.57 mL
1 mM	2.88 mL	14.39 mL	28.79 mL
5 mM	0.58 mL	2.88 mL	5.76 mL

*The above data is based on the productmolecular weight 347.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.