ICI-118551

Catalog No. A15878

ICI-118551是选择性的β2肾上腺素能受体（肾上腺素受体）拮抗剂。

Product Citations

Moon Jain, .et al. Involvement of angiotensin II and beta-adrenergic receptors in the regulation of autophagy in human endothelial EA.hy926 cell line, Tropical Journal of Pharmaceutical Research, 2020, Vol. 19 No. 4

Technical details

Catalog Num	A15878
M. Wt	313.86
Formula	C17H27NO2.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1217094-53-5
Synonyms	ICI118551, ICI 118551
SMILES	CC1=C(CCC2)C2=C(OC[C@H](O)[C@@H](C)NC(C)C)C=C1.Cl

Biological Activity

ICI-118551是选择性的β2肾上腺素能受体（肾上腺素受体）拮抗剂。

Targets

β2-adrenergic receptor	β1-adrenergic receptor	β3-adrenoceptor
0.7nM(Ki)	49.5nM(Ki)	611nM(Ki)

Solubility *

In vitro	DMSO	59 mg/mL (187.98 mM)
	Water	20 mg/mL (63.71 mM)
	Ethanol	59 mg/mL (187.98 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.86 mL	159.31 mL	318.61 mL
0.5 mM	6.37 mL	31.86 mL	63.72 mL
1 mM	3.19 mL	15.93 mL	31.86 mL
5 mM	0.64 mL	3.19 mL	6.37 mL

*The above data is based on the productmolecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.