GNF-7

Catalog No. A15887

GNF-7是一种有效的II型激酶Bcr-Abl抑制剂,对于M351T,T315I,E255 V,G250E和c-Abl,IC50分别<5 nM,61 nM,122 nM,136 nM和133 nM。
Catalog Num A15887
M. Wt 547.53
Formula C28H24F3N7O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 839706-07-9
Synonyms GNF7, GNF 7
SMILES O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
GNF-7是一种有效的II型激酶Bcr-Abl抑制剂,对于M351T,T315I,E255 V,G250E和c-Abl,IC50分别<5 nM,61 nM,122 nM,136 nM和133 nM。
Targets
M351T T315I E255V c-Abl G250E
<5 nM61 nM122 nM133 nM136 nM
In vitro DMSO 17 mg/mL (31.04 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.26 mL 91.32 mL 182.64 mL
0.5 mM 3.65 mL 18.26 mL 36.53 mL
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL

*The above data is based on the productmolecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.