Ripasudil

Catalog No. A15888

Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

Technical details

Catalog Num	A15888
M. Wt	395.88
Formula	C15H23ClFN3O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	887375-67-9
Synonyms	K 115, K115, K-115
SMILES	CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)F.O.O.Cl

Biological Activity

Ripasudil (K-115) is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

Targets

ROCK2	ROCK1
19 nM	51 nM

Solubility *

In vitro	DMSO	Warmed: 25 mg/mL (63.14 mM)
	Water	76 mg/mL (191.97 mM)
	Ethanol	Warmed: 5 mg/mL (12.63 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.26 mL	126.3 mL	252.6 mL
0.5 mM	5.05 mL	25.26 mL	50.52 mL
1 mM	2.53 mL	12.63 mL	25.26 mL
5 mM	0.51 mL	2.53 mL	5.05 mL

*The above data is based on the productmolecular weight 395.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.