K03861

Catalog No. A15889

K03861是II型CDK2抑制剂，其CDK2（WT），CDK2（C118L），CDK2（A144C）和CDK2（C118L/A144C）的Kd分别为50 nM，18.6 nM，15.4 nM和9.7 nM。

Technical details

Catalog Num	A15889
M. Wt	501.5
Formula	C24H26F3N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	853299-07-7
Synonyms	K 03861, K-03861
SMILES	CN1CCN(CC2=C(C(F)(F)F)C=C(/N=C(O)/NC3=CC=C(OC(C=CN4)=NC4=N)C=C3)C=C2)CC1

Biological Activity

K03861是II型CDK2抑制剂，其CDK2（WT），CDK2（C118L），CDK2（A144C）和CDK2（C118L/A144C）的Kd分别为50 nM，18.6 nM，15.4 nM和9.7 nM。

Targets

CDK2(C118L/A144C)	CDK2(A144C)	CDK2(C118L)	CDK2(WT)
9.7 nM(Kd)	15.4 nM(Kd)	18.6 nM(Kd)	50 nM(Kd)

Solubility *

In vitro	DMSO	97 mg/mL (193.42 mM)
	Water	Insoluble
	Ethanol	15 mg/mL (29.91 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.94 mL	99.7 mL	199.4 mL
0.5 mM	3.99 mL	19.94 mL	39.88 mL
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.4 mL	1.99 mL	3.99 mL

*The above data is based on the productmolecular weight 501.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.