AMG319

Catalog No. A15901

AMG319是一种有效的选择性PI3Kδ抑制剂,IC50为18 nM,选择性是其他PI3K的47倍以上。
Catalog Num A15901
M. Wt 385.4
Formula C21H16FN7
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1608125-21-8
Synonyms AMG-319, AMG 319
SMILES C[C@@](NC1=NC=NC2=C1N=CN2)([H])C(C=C3C=CC(F)=CC3=N4)=C4C5=CC=CC=N5
AMG319是一种有效的选择性PI3Kδ抑制剂,IC50为18 nM,选择性是其他PI3K的47倍以上。
Targets
PI3Kδ PI3Kγ PI3Kβ PI3Kα
18 nM850 nM2.7μM33 μM
In vitro DMSO 72 mg/mL (186.82 mM)
Water Insoluble
Ethanol 72 mg/mL (186.82 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.95 mL 129.74 mL 259.47 mL
0.5 mM 5.19 mL 25.95 mL 51.89 mL
1 mM 2.59 mL 12.97 mL 25.95 mL
5 mM 0.52 mL 2.59 mL 5.19 mL

*The above data is based on the productmolecular weight 385.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.