CPI-360

Catalog No. A15908

CPI-360是一种有效的，选择性的且具有SAM竞争性的EZH2抑制剂，IC50为102.3 nM，选择性是其他甲基转移酶的100倍以上。

Technical details

Catalog Num	A15908
M. Wt	437.53
Formula	C25H31N3O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1802175-06-9
Synonyms	CPI360, CPI 360
SMILES	CC(N1)=CC(OC)=C(CNC(C2=C(C)N([C@H](C)C3CCOCC3)C4=C2C=CC=C4)=O)C1=O

Biological Activity

CPI-360是一种有效的，选择性的且具有SAM竞争性的EZH2抑制剂，IC50为102.3 nM，选择性是其他甲基转移酶的100倍以上。

Targets

EZH2
0.25 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 18 mg/mL (41.14 mM)
	Water	Insoluble
	Ethanol	Warmed: 16 mg/mL (36.57 mM)
In vivo	10% DMSO+60% PEG 400+ddH2O	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.86 mL	114.28 mL	228.56 mL
0.5 mM	4.57 mL	22.86 mL	45.71 mL
1 mM	2.29 mL	11.43 mL	22.86 mL
5 mM	0.46 mL	2.29 mL	4.57 mL

*The above data is based on the productmolecular weight 437.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.