CPI-169

Catalog No. A15920

CPI-169是一种有效的选择性EZH2抑制剂,对EZH2 WT,EZH2 Y641N和EZH1的IC50分别为0.24 nM,0.51 nM和6.1 nM。
Catalog Num A15920
M. Wt 528.66
Formula C27H36N4O5S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1450655-76-1
Synonyms CPI 169, CPI169
SMILES CCS(N1CCC([C@@](N2C(C)=C(/C(O)=N/CC(C(O)=N3)=C(OC)C=C3C)C4=CC=CC=C42)([H])C)CC1)(=O)=O
CPI-169是一种有效的选择性EZH2抑制剂,对EZH2 WT,EZH2 Y641N和EZH1的IC50分别为0.24 nM,0.51 nM和6.1 nM。
Targets
EZH2 WT EZH2 Y641N EZH1
0.24 nM0.51 nM6.1 nM
In vitro (25°C) DMSO 88 mg/mL (166.45 mM)
Water Insoluble
Ethanol 88 mg/mL (166.45 mM)
In vivo 10% DMSO+60% PEG 400+30% ddH2O 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.92 mL 94.58 mL 189.16 mL
0.5 mM 3.78 mL 18.92 mL 37.83 mL
1 mM 1.89 mL 9.46 mL 18.92 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 528.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.