SIS3

Catalog No. A16065

SIS3是Smad3的新型特异性抑制剂。它对转化生长因子-β1诱导的细胞外基质表达有影响。
  • Miao Deng, .et al. pH-Triggered Copper-Free Click Reaction-Mediated Micelle Aggregation for Enhanced Tumor Retention and Elevated Immuno-Chemotherapy against Melanoma, ACS Appl Mater Interfaces, 2021, Apr 21;13(15):18033-18046 PMID: 33834754
  • Wei P, .et al. Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis, Cell Death Dis, 2019, Sep 11;10(9):670 PMID: 31511493
Catalog Num A16065
M. Wt 489.99
Formula C28H27N3O3.HCl
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 521984-48-5
Synonyms SIS 3
SMILES CN1C(C2=CC=CC=C2)=C(C3=C1N=CC=C3)/C([H])=C([H])/C(N4CCC5=CC(OC)=C(OC)C=C5C4)=O.Cl
SIS3是Smad3的新型特异性抑制剂。它对转化生长因子-β1诱导的细胞外基质表达有影响。
Targets
Smad3
In vitro (25°C) DMSO 92 mg/mL (187.76 mM)
Water Insoluble
Ethanol 23 mg/mL (46.94 mM)
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.41 mL 102.04 mL 204.09 mL
0.5 mM 4.08 mL 20.41 mL 40.82 mL
1 mM 2.04 mL 10.2 mL 20.41 mL
5 mM 0.41 mL 2.04 mL 4.08 mL

*The above data is based on the productmolecular weight 489.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.