LY3023414

Catalog No. A16126

LY3023414是从专利WO/2012097039A1（化合物实施例1）中提取的I类PI3K同种型，mTOR和DNA-PK的口服ATP竞争性抑制剂，对Akt1（pT308）的IC50为64.9 nM，42.1 nM，10.6 nM和19.1 nM。），Akt1（pS473），P70S6（pT389），S6RP（pS240/242）。

Product Citations

Zou Y, .et al. Targeting PI3K-AKT-mTOR by LY3023414 inhibits human skin squamous cell carcinoma cell growth in vitro and in vivo, Biochem Biophys Res Commun, 2017, Aug 19;490(2):385-392 PMID: 28623128

Technical details

Catalog Num	A16126
M. Wt	406.49
Formula	C23H26N4O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1386874-06-1
Synonyms	LY-3023414, LY 3023414
SMILES	CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC

Biological Activity

Targets

class I PI3K isoforms	mTOR kinase	DNA-PK

Solubility *

In vitro	DMSO	44 mg/mL (108.24 mM)
	Water	Insoluble
	Ethanol	57 mg/mL (140.22 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.6 mL	123 mL	246.01 mL
0.5 mM	4.92 mL	24.6 mL	49.2 mL
1 mM	2.46 mL	12.3 mL	24.6 mL
5 mM	0.49 mL	2.46 mL	4.92 mL

*The above data is based on the productmolecular weight 406.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.