Dolutegravir Sodium

Catalog No. A16162

Dolutegravir Sodium是一种HIV整合酶抑制剂（IC50 = 2.7 nM），对耐raltegravir的签名突变体Y143R，Q148K，N155H和G140S/Q148H具有中等活性。

Technical details

Catalog Num	A16162
M. Wt	441.36
Formula	C20H18F2N3NaO5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1051375-19-9
Synonyms	DTG, GSK1349572
SMILES	CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]

Biological Activity

Dolutegravir Sodium是一种HIV整合酶抑制剂（IC50 = 2.7 nM），对耐raltegravir的签名突变体Y143R，Q148K，N155H和G140S/Q148H具有中等活性。

Targets

HIV integrase
2.7 nM

Solubility *

In vitro	DMSO	0.18 mg/mL (0.41 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.66 mL	113.29 mL	226.57 mL
0.5 mM	4.53 mL	22.66 mL	45.31 mL
1 mM	2.27 mL	11.33 mL	22.66 mL
5 mM	0.45 mL	2.27 mL	4.53 mL

*The above data is based on the productmolecular weight 441.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.