A-1331852

Catalog No. A16190

A-1331852是有效的选择性BCL-XL抑制剂。BCL-XL是主要的抗凋亡生存蛋白，可能是CML中的新型治疗靶标。

Technical details

Catalog Num	A16190
M. Wt	658.82
Formula	C38H38N6O3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1430844-80-6
Synonyms	A 1331852, A1331852
SMILES	CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O

Biological Activity

A-1331852是有效的选择性BCL-XL抑制剂。BCL-XL是主要的抗凋亡生存蛋白，可能是CML中的新型治疗靶标。

Targets

Bcl-xL	Bcl-w	Bcl-2	Mcl-1
<0.01 nM(Ki)	4 nM(Ki)	6 nM(Ki)	142 nM(Ki)

Solubility *

In vitro	DMSO	91 mg/mL (138.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.18 mL	75.89 mL	151.79 mL
0.5 mM	3.04 mL	15.18 mL	30.36 mL
1 mM	1.52 mL	7.59 mL	15.18 mL
5 mM	0.3 mL	1.52 mL	3.04 mL

*The above data is based on the productmolecular weight 658.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.