RK-33

Catalog No. A16194

RK-33是有效的选择性DDX3抑制剂。RK-33与DDX3结合并取消其活性。

Product Citations

Yang SNY, .et al. RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X, Cells, 2020, Jan 9;9(1). PMID: 31936642
Zhang S, .et al. Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics, Sci Rep, 2020, Jan 31;10(1):1557 PMID: 32005838

Technical details

Catalog Num	A16194
M. Wt	428.45
Formula	C23H20N6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1070773-09-9
Synonyms	RK 33, RK33
SMILES	O=C1N(CC2=CC=C(OC)C=C2)C3=NC=NC4=C(N=CN4CC5=CC=C(OC)C=C5)C3=N1

Biological Activity

RK-33是有效的选择性DDX3抑制剂。RK-33与DDX3结合并取消其活性。

Targets

DDX3

Solubility *

In vitro	DMSO	76 mg/mL (177.38 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.7 mL	233.4 mL
0.5 mM	4.67 mL	23.34 mL	46.68 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

*The above data is based on the productmolecular weight 428.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.