Nintedanib esylate

Catalog No. A16197

Nintedanib esylate是多种受体酪氨酸激酶（RTK）和非受体酪氨酸激酶（nRTK）的有效抑制剂。

Product Citations

Thibaut Fourniols, .et al. Inhibition of Colorectal Cancer-Associated Fibroblasts by Lipid Nanocapsules Loaded With Acriflavine or Paclitaxel, Int J Pharm, 2020, Jun 30;584:119337 PMID: 32371002
Majid Momeny, .et al. Cediranib, an inhibitor of vascular endothelial growth factor receptor kinases, inhibits proliferation and invasion of prostate adenocarcinoma cells, Eur J Pharmacol, 2020, 882:173298

Technical details

Catalog Num	A16197
M. Wt	649.76
Formula	C33H39N5O7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	656247-18-6
Synonyms	BIBF-1120 esylate
SMILES	O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C)CC4)=O)C=C3)/C5=CC=CC=C5)OC.CCS(=O)(O)=O

Biological Activity

Nintedanib esylate是多种受体酪氨酸激酶（RTK）和非受体酪氨酸激酶（nRTK）的有效抑制剂。

Solubility *

In vitro	DMSO	89 mg/mL (136.97 mM)
	Water	89 mg/mL (136.97 mM)
	Ethanol	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.39 mL	76.95 mL	153.9 mL
0.5 mM	3.08 mL	15.39 mL	30.78 mL
1 mM	1.54 mL	7.7 mL	15.39 mL
5 mM	0.31 mL	1.54 mL	3.08 mL

*The above data is based on the productmolecular weight 649.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.