LOXO-101 sulfate

Catalog No. A16239

LOXO-101 sulfate是一种小分子，设计用于阻断TRK家族的ATP结合位点，对TRKA，TRKB和TRKC激酶具有2至20 nM的细胞效力。

Technical details

Catalog Num	A16239
M. Wt	526.51
Formula	C21H24F2N6O6S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1223405-08-0
Synonyms	LOXO101 sulfate, LOXO 101 sulfate
SMILES	C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O

Biological Activity

LOXO-101 sulfate是一种小分子，设计用于阻断TRK家族的ATP结合位点，对TRKA，TRKB和TRKC激酶具有2至20 nM的细胞效力。

Targets

TRK

Solubility *

In vitro	DMSO	88 mg/mL (167.13 mM)
	Water	Insoluble
	Ethanol	88 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.99 mL	94.96 mL	189.93 mL
0.5 mM	3.8 mL	18.99 mL	37.99 mL
1 mM	1.9 mL	9.5 mL	18.99 mL
5 mM	0.38 mL	1.9 mL	3.8 mL

*The above data is based on the productmolecular weight 526.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.