GDC-0084

Catalog No. A16272

GDC-0084是一种具有潜在抗肿瘤活性的磷脂酰肌醇3-激酶（PI3K）抑制剂。

Technical details

Catalog Num	A16272
M. Wt	382.428
Formula	C18H22N8O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1382979-44-3
Synonyms	RG7666
SMILES	NC1=NC=C(C2=NC(N3CCOCC3)=C4N=C(C(C)(C)OCC5)N5C4=N2)C=N1

Biological Activity

GDC-0084是一种具有潜在抗肿瘤活性的磷脂酰肌醇3-激酶（PI3K）抑制剂。

Targets

PI3Kα
2 nM(Ki)

Solubility *

In vitro	DMSO	8 mg/mL (20.91 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.15 mL	130.74 mL	261.49 mL
0.5 mM	5.23 mL	26.15 mL	52.3 mL
1 mM	2.61 mL	13.07 mL	26.15 mL
5 mM	0.52 mL	2.61 mL	5.23 mL

*The above data is based on the productmolecular weight 382.428. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.