TGR-1202 (Umbralisib)

Catalog No. A16277

TGR-1202是口服的下一代PI3Kδ抑制剂，在基于酶和细胞的测定中抑制PI3Kδ活性，IC50和EC50值分别为22.2和24.3 nM。

Technical details

Catalog Num	A16277
M. Wt	571.55
Formula	C31H24F3N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1532533-67-7
Synonyms	RP5264, TGR1202, TGR 1202, RP-5264, RP 5264
SMILES	CC(C)OC1=C(C=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)C4=C(C(=O)C5=C(O4)C=CC(=C5)F)C6=CC(=CC=C6)F)F

Biological Activity

TGR-1202是口服的下一代PI3Kδ抑制剂，在基于酶和细胞的测定中抑制PI3Kδ活性，IC50和EC50值分别为22.2和24.3 nM。

Solubility *

In vitro (25°C)	DMSO	Warmed: 92 mg/mL (160.96 mM)
	Water	Insoluble
	Ethanol	Warmed: 6 mg/mL
In vivo	2% DMSO+30% PEG 300+2% Tween 80+H2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.5 mL	87.48 mL	174.96 mL
0.5 mM	3.5 mL	17.5 mL	34.99 mL
1 mM	1.75 mL	8.75 mL	17.5 mL
5 mM	0.35 mL	1.75 mL	3.5 mL

*The above data is based on the productmolecular weight 571.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

TGR-1202 (Umbralisib)

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions