HTH-01-015

Catalog No. A16281

HTH-01-015是NUAK1的有效和选择性抑制剂（IC50 = 100 nM），并且不影响包括其他AMPK家族成员在内的139种其他激酶的活性。

Technical details

Catalog Num	A16281
M. Wt	468.56
Formula	C26H28N8O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1613724-42-7
Synonyms	HTH01-015, HTH 01-015
SMILES	CC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1

Biological Activity

HTH-01-015是NUAK1的有效和选择性抑制剂（IC50 = 100 nM），并且不影响包括其他AMPK家族成员在内的139种其他激酶的活性。

Targets

NUAK1	NUAK2
100 nM	>10 μM

Solubility *

In vitro	DMSO	Warmed: 54 mg/mL (115.24 mM)
	Water	Insoluble
	Ethanol	28 mg/mL (59.75 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.34 mL	106.71 mL	213.42 mL
0.5 mM	4.27 mL	21.34 mL	42.68 mL
1 mM	2.13 mL	10.67 mL	21.34 mL
5 mM	0.43 mL	2.13 mL	4.27 mL

*The above data is based on the productmolecular weight 468.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.