(+)-Apogossypol
Catalog No. A16316
(+)-Apogossypol是Bcl-2家族蛋白的有效抑制剂。与Bcl-2，Bcl-XL，Mcl-1，Bcl-W和Bcl-B上的BH3肽结合位点竞争，但与Bfl-1竞争，IC50为0.5至2μM。
| Catalog Num | A16316 |
|---|---|
| M. Wt | 462.53 |
| Formula | C28H30O6 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 66389-74-0 |
| Synonyms | Apogossypol, NSC736630 |
| SMILES | CC(C=C1C(C(C)C)=C(O)C(O)=CC1=C2O)=[C@]2[C@@]3=C(C)C=C4C(C=C(O)C(O)=C4C(C)C)=C3O |
(+)-Apogossypol是Bcl-2家族蛋白的有效抑制剂。与Bcl-2，Bcl-XL，Mcl-1，Bcl-W和Bcl-B上的BH3肽结合位点竞争，但与Bfl-1竞争，IC50为0.5至2μM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.62 mL | 108.1 mL | 216.2 mL |
| 0.5 mM | 4.32 mL | 21.62 mL | 43.24 mL |
| 1 mM | 2.16 mL | 10.81 mL | 21.62 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
*The above data is based on the productmolecular weight 462.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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