AZD8835

Catalog No. A16352

AZD8835是一种有效的选择性PI3Kα和PI3Kδ抑制剂，IC50为5.7 nM和6.2 nM，对PI3Kβ（IC50 431 nM）和PI3Kγ（IC50 90 nM）具有选择性。

Product Citations

James T. Lynch, etc. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget. 2016 Apr 19; 7(16): 22128–22139.

Technical details

Catalog Num	A16352
M. Wt	469.54
Formula	C22H31N9O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1620576-64-8
Synonyms	AZD 8835, AZD-8835
SMILES	O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO

Biological Activity

AZD8835是一种有效的选择性PI3Kα和PI3Kδ抑制剂，IC50为5.7 nM和6.2 nM，对PI3Kβ（IC50 431 nM）和PI3Kγ（IC50 90 nM）具有选择性。

Solubility *

In vitro	DMSO	83 mg/mL (176.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.3 mL	106.49 mL	212.97 mL
0.5 mM	4.26 mL	21.3 mL	42.59 mL
1 mM	2.13 mL	10.65 mL	21.3 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

*The above data is based on the productmolecular weight 469.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.