EPZ020411
Catalog No. A16377
EPZ020411是PRMT6的有效和选择性抑制剂，IC50为10 nM，对PRMT6的选择性是PRMT1和PRMT8的10倍以上。
- Tianzhi Huang, .et al. PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells, Mol Cell, 2021, Mar 18;81(6):1276-1291 PMID: 33539787
| Catalog Num | A16377 |
|---|---|
| M. Wt | 442.59 |
| Formula | C25H38N4O3 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1700663-41-7 |
| Synonyms | EPZ-020411 |
| SMILES | CN(CC1=CNN=C1C2=CC=C(O[C@@H]3C[C@@H](OCCC4CCOCC4)C3)C=C2)CCNC |
EPZ020411是PRMT6的有效和选择性抑制剂，IC50为10 nM，对PRMT6的选择性是PRMT1和PRMT8的10倍以上。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.59 mL | 112.97 mL | 225.94 mL |
| 0.5 mM | 4.52 mL | 22.59 mL | 45.19 mL |
| 1 mM | 2.26 mL | 11.3 mL | 22.59 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
*The above data is based on the productmolecular weight 442.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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