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Edoxaban

促销

Factor Xa 抑制剂

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产品目录号: A14317

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Edoxaban 10mg A14317-10
¥ 1,000.00
Edoxaban 25mg A14317-25
¥ 2,000.00
Edoxaban 50mg A14317-50
¥ 3,500.00
Edoxaban 10mM * 1mL in DMSO A14317-10mM-D
¥ 1,300.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM

Edoxaban

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Edoxaban 发表的文献 (1)
  • Dani?l Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343

Chemical Information

目录号 A14317
Mechanism of action Inhibitor
分子量 738.27
化学分子式 C24H30ClN7O4S.C7H8O3S.H2O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1229194-11-9
Synonyms DU-176b
SMILES code CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O
化学名称 Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate

生物活性

Description
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM
Targets
Factor Xa Thrombin FIXa
0.561 nM(Ki)6 μM(Ki)41.7 μM(Ki)

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (135.45 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.55 mL 67.73 mL 135.45mL
0.5 mM 2.71 mL 13.55 mL 27.09 mL
1 mM 1.35 mL 6.77 mL 13.55 mL
5 mM 0.27 mL 1.35 mL 2.71 mL

*The above data is based on the productmolecular weight 738.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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