FAK

Inhibitory Selectivity

Catalog No.	Inhibitor Name	FAK	Other
A12580	PF-00562271	****	CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11192	PF-562271	****	CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11235	PF-573228	*
A11507	TAE226	**	Insulin Receptor,IGF-1R,c-Met
A11171	PF-03814735	*	Aurora A,Aurora B,FLT1
A11142	PF-431396	**
A13140	PND-1186	****
A11929	Defactinib
A15543	CEP-37440	**	ALK
A15765	GSK2256098	****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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NVP-TAE 226

Catalog No. A11507
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FAK 抑制剂

NVP-TAE 226是一种强效FAK抑制剂，IC50为5.5 nM，对pyk2(IC50=3.5 nM)有适度的强效作用；对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。了解更多

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PF-00562271

Catalog No. A12580
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FAK 抑制剂

PF-00562271是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK和Pyk2抑制剂，IC50分别为1.5 nM和14 nM。了解更多

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PF-4618433

Catalog No. A13461
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PYK2/FAK 抑制剂

PF-4618433与原型BIRB796相比，PF-4618433显示出PYK2效价提高、p38活性降低和总体选择性优越。了解更多

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PF 431396

Catalog No. A11142
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FAK/PYK2 抑制剂

PF 431396是一种双粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（PYK2）抑制剂（IC50值分别为2和11 nM）。了解更多

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